SERMS are Selective Estrogen Receptor Modulators, drugs that are FDA-approved for preventing and treating osteoporosis in women who have passed the menopause. These pills work on the same basis of estrogen therapy. They are a class of drugs that replace estrogen in women and help reduce the effect that this hormone change has on the body. The primary SERM available is called Evista, which was approved back in 2007 to treat the condition. The medication has already been proven to reduce the chance of developing fractures on the spine or the hip.
Denosumab (or Prolia) is one of the newer kinds of medication being used by doctors across the United States and beyond to reduce the risk of men and women experiencing fractures as a result of osteoporosis. The medication is not related to bisphosphonates, meaning that it’s a great alternative for people who cannot take bisphosphonates for whatever reason. For instance, many people are unable to take the aforementioned medication as a result of poor kidney health, making denosumab a great alternative.